|     home    |     search     |     content     |     mail     |     login     |

study information

studycode99372981
date of publication20-jul-1999
journalAIDS Res Hum Retroviruses 1999 Jul 20;15(11):973-81
titleLymphoproliferative response to HIV type 1 p24 in long-term survivors of HIV type 1 infection is predictive of persistent AIDS-free infection.
title in Dutch
PubMedID10445809
include
resp. centreCLB
designTo establish immunologic correlates of progression to AIDS in long-term survivors of HIV-1 infection, HIV-1-specific T cell-mediated responses, together with T cell reactivity to recall antigens, were studied in frozen samples collected after 5 and 8 years of documented HIV-1 infection. Eight of 21 homosexual men, who remained asymptomatic and maintained CD4+ T cell numbers >400 cells/microl for 9 years of HIV-1 infection, progressed to AIDS (CDC 1993 definition) within 12.5 years of infection (late progressors, LPs). The remainders showed minimal deterioration of immune parameters (long-term nonprogressors, LTNPs). CD4+ T cell numbers and T cell function measured at years 5 and 8 of follow-up were comparable in the two groups. At both time points responses to recall antigens did not significantly differ between the two groups, although a significant decline of lymphoproliferative responses to Candida and tetanus toxoid was observed in LPs. Circulating HIV-1-specific cytotoxic T lymphocyte precursors were found in broad frequency ranges in both LPs and LTNPs and, similarly, no significant differences were found in comparing the breadth of serum neutralizing activity against heterologous HIV-1 primary isolates. In contrast, lymphoproliferative responses to p24gag, but not p17gag or gp160env, were detected only in LTNPs and were totally absent in LPs at both time points (p < 0.01). Our data suggest that the presence of circulating p24-specific CD4+ T cells may reflect effective viral control and be predictive of subsequent favorable clinical course in long-term asymptomatic individuals.


Use this form to to view general information about a study.
  • click on 'authors' to view the list of authors who contributed
  • click on 'files' to view a list of files, associated with this study: these files can be of any type: f.i. the full text of the article, or code used in the analysis, or a Powerpoint demonstration.
  • click on 'tables' to view a list of the database tables that were used in this study: more is information on these tables is available.
  • for studies related to the Amsterdam Cohort, the option 'progress' is available: it gives information about the process of collecting information about a study: who was asked for information, when was this done, is the information complete, etc.
  • if you have the authority to change data about the study, the option 'edit' is available: clicking this will take you to a form for editing the main information, with options to edit all aspects.
  • clicking on the PubMedID opens a new browser window with PubMed
  • clicking on the 'resp. centre' gives a list of all studies for this centre
  • click the 'back' button to go to the previous document