|     home    |     search     |     content     |     mail     |     login     |

table information

     

tablecode1328
nametblMT2
physical fileACS_Biobank acs_biobank  (SQL Server 2005)
description
comment short
comment longDetermination of HIV-1 co-receptor use using the MT-2 cell line. MT-2 cells are of human origin, more specifically a CD4 positive T-cell lymphoma, which is HTLV-1 infected. MT2 cells express high levels of the C-X-C chemokine receptor 4 (CXCR4) and hence can be infected by HIV-1 variants that use this receptor alone (X4 variants) or in combination with CCR5 (R5X4 variants). Infection of MT-2 cells results in a cytopathic effect called syncytium formation (fusions between 2 or more cells) that can easily be detected microscopically. HIV-1 variants that infect MT-2 cells are thus scored as syncytium inducing (SI) variants. HIV-1 variants that do not infect MT-2 cells are scored as non-syncytium inducing (NSI) variants. The test is performed by direct co-cultivation of patient-derived peripheral blood mononuclear cells (PBMC) of with MT-2 cells. This culture is maintained for 4 weeks with twice weekly passage and microscopic observation after which the test result is reported. The presence of X4 variants in blood is associated with an accelerated disease progression (Koot, Annals of Internal Medicine, Vol. 118; 9, 1 May 1993).
number of records12826
startdate
stopdate
resp. centreGGD
record24-nov-2014 16:22


This screen displays information about a table.
  • click on "fields" to view information about the fields of this table
  • click on "studies" to view a list of studies that used this table
  • click on "SPSS labels" to generate an SPSS syntax file with field and variable labels
  • click on "code books" to view a list of codebooks that reference this table
  • click on "ID's" to view more information about the ID's in this table (only available with sufficient rights)
  • faq