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table information


physical fileACS_Biobank acs_biobank  (SQL Server 2005)
comment short
comment longDetermination of HIV-1 co-receptor use using the MT-2 cell line. MT-2 cells are of human origin, more specifically a CD4 positive T-cell lymphoma, which is HTLV-1 infected. MT2 cells express high levels of the C-X-C chemokine receptor 4 (CXCR4) and hence can be infected by HIV-1 variants that use this receptor alone (X4 variants) or in combination with CCR5 (R5X4 variants). Infection of MT-2 cells results in a cytopathic effect called syncytium formation (fusions between 2 or more cells) that can easily be detected microscopically. HIV-1 variants that infect MT-2 cells are thus scored as syncytium inducing (SI) variants. HIV-1 variants that do not infect MT-2 cells are scored as non-syncytium inducing (NSI) variants. The test is performed by direct co-cultivation of patient-derived peripheral blood mononuclear cells (PBMC) of with MT-2 cells. This culture is maintained for 4 weeks with twice weekly passage and microscopic observation after which the test result is reported. The presence of X4 variants in blood is associated with an accelerated disease progression (Koot, Annals of Internal Medicine, Vol. 118; 9, 1 May 1993).
number of records12826
resp. centreGGD
record24-nov-2014 16:22

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